What happens when you’ve done everything right—but IVF still doesn’t work? Many women find themselves questioning not only the effectiveness of IVF, but also whether repeated fertility treatments could affect their long-term health.
If you’ve reached the point where fear, sadness, frustration or fatigue has taken over, it may be time to consider a different path.
In this article, we break down the science behind IVF and cancer risk—what studies say, what to do when IVF continues to fail and why surrogacy with American Surrogacy might be the path that finally brings your dreams of parenthood to life.
If you’re ready to explore a path beyond repeated IVF failures, reach out to American Surrogacy today. Let us help you become parents sooner.
Can Multiple Rounds of IVF Cause Cancer?
No—there is no clinically significant evidence that IVF causes cancer, even after multiple rounds.
If you’ve been through multiple IVF cycles without success, the emotional and physical toll can be overwhelming. It’s not just disappointment—it’s deep sadness, fatigue and frustration that builds with every failed attempt.
At some point, it’s only natural to wonder: Could this be doing more harm than good?
In the sections ahead, we’ll explore what studies say and how to think about next steps, especially if you’re starting to feel like IVF may no longer be the best path forward.
Can IVF cause breast cancer?
In short, no, IVF does not cause breast cancer, even if you’ve had multiple cycles.
Some early studies raised concerns, but more recent cohort studies show no consistent association between fertility treatments and breast cancer risk. Any observed increases may be due to higher baseline risk in women with infertility, not the fertility drugs.
Can IVF cause ovarian cancer?
There is no detectable increase in ovarian cancer risk from undergoing IVF, according to a meta-analysis of 37 studies including over 4 million women.
Ovarian cancer has also been studied heavily in relation to fertility treatments. Earlier studies suggested a possible link, but new research has identified two key issues:
- Age correlation: The average IVF patient is older, and age naturally increases ovarian cancer risk.
- Selection bias: Women with unexplained infertility—who often undergo IVF—already have higher baseline risks.
Can IVF cause cervical cancer?
Currently, women who undergo IVF are about 0.1% less likely to develop cervical cancer, and about 0.1% more likely to develop benign or borderline cervical tumors.
On the surface, this might seem like IVF itself lowers cancer rates, but the truth is much simpler:
- IVF patients have more cervical exams.
- Early detection of abnormal cells leads to earlier treatment.
This lends further emphasis to the importance of scheduling regular Pap smears and wellness exams, even if you are currently undergoing IVF.
Can IVF cause uterine or endometrial cancer?
A large Australian study found:
- 1.09% risk in IVF patients
- 2.64% risk in infertile women who did not do IVF
This suggests that IVF may even have a protective effect, likely because of close monitoring during treatment.
What If Your IVF Keeps Failing?
While repeated IVF attempts may not put you at higher risk of cancer, we also know how frustrating and painful repeated IVF cycles can be—physically, emotionally and financially.
Some couples and individuals experience unsuccessful IVF treatments over and over again, with seemingly no reason for failure.
Here are a few medically recognized reasons for repeated IVF failure:
- Poor ovarian response: Some ovaries simply don’t respond well to stimulation drugs, leading to fewer or lower-quality eggs.
- Chromosomal issues: Embryos with genetic abnormalities are a major cause of both miscarriage and failed implantation, even in IVF.
- Immune system barriers: Sometimes the body’s immune defenses mistakenly treat embryos as invaders, preventing implantation.
- Endometriosis: Endometrial tissue can make the uterus less receptive to embryos—even when fertilization is successful.
If your IVF has failed more than twice, it’s time to speak with a reproductive endocrinologist to explore deeper diagnostics.
When IVF Keeps Failing, it May Be Time to Consider Surrogacy
As much as you may want to keep trying, there comes a point where another IVF cycle may not increase your odds.
Knowing when to pivot can save you emotional heartache and bring you closer to building your family another way.
Here are signs you might be ready to consider surrogacy:
- You’ve had multiple failed IVF rounds with no clear cause
- Doctors say your uterus may not support pregnancy
- You’ve experienced severe side effects from IVF medication
- You’re emotionally and financially exhausted
Learn more about moving on from IVF, practically and emotionally.
Why Surrogacy is a Good Alternative to IVF: How You Can Have More Time as a Parent
If your eggs or embryos are viable, but your body can’t carry a pregnancy, surrogacy with American Surrogacy can be a life-changing option. It allows you to:
- Use your own embryos (from prior IVF cycles)
- Match with a thoroughly prescreened surrogate
- Remain closely involved throughout the journey, from matching to prenatal appointments and delivery day
At American Surrogacy, every surrogate is thoroughly screened, emotionally evaluated and has previously completed at least one healthy pregnancy and delivery.
Our agency has helped thousands of intended parents navigate the surrogacy journey with confidence and clarity.
“I don’t know how long we would have been mourning the loss of not having another child. I don’t know how long that lasts because surrogacy gave us hope through the entire time that we were trying to have this baby. We knew it could be done. It was just a matter of not giving up and finding the right people to help us.”
–Bekah and Gilad, parents through surrogacy.
What’s Next?
You’ve already shown incredible strength by going through the IVF process. If it hasn’t worked, that doesn’t mean your journey is over.
You’re still on the path to parenthood—and we’re here to help. Curious about next steps? Contact us today to learn how surrogacy can turn heartbreak into hope.