You went through the emotional rollercoaster of in vitro fertilization once before, and after all the stress and waiting, it worked. Now you’re ready to grow your family again, but IVF for a second baby isn’t working.

Fertility can change, and what worked for you the first time may not work the second, but understanding why and what your next steps are can give you hope.

In this article, we’ll explore why treatment may not be working and provide alternative paths like surrogacy.

If you’re feeling stuck, know that you have options — and we’re here to help you explore them. Contact us today for more information.

Why is Achieving a second IVF pregnancy So Hard?

Failing to achieve a second IVF pregnancy can be frustrating when growing your family. You might not be sure why it’s so hard after you experienced success the first time.

While every situation is different, several common factors can make getting pregnant after IVF success harder:

• Age-related fertility decline: As you age, egg quality and quantity naturally decrease, leading to a higher chance of miscarriage and lower chances of embryo implantation.
• Uterine changes from previous pregnancy: Sometimes, changes in the uterine lining after carrying a pregnancy can make implantation more difficult, especially if there is scarring or other complications.
• Diminished ovarian reserve: With fewer eggs available for retrieval, you might not have as many viable embryos to work with compared to your first IVF cycle.
• Unexplained infertility: Sometimes, no clear medical reason is found for why IVF isn’t working.

What Are the Chances of a Second IVF Success?

After a live birth from IVF, your chances of a second IVF success after an IVF baby are generally high, ranging from 51% to 88% after six cycles.

Many factors can change between pregnancies, making the process more challenging the second time around. For example, as you get older, the health of your uterus and your hormone levels can decline, which can impact IVF outcomes.

Additionally, the stress and anxiety can impact both your mental and physical well-being, so it’s important to take care of yourself throughout this process.

See how the success rates of surrogacy compare to IVF.

When Should You Consider Surrogacy?

After failed IVF for a second baby or complications from a previous pregnancy, surrogacy could be the right option for you.

Surrogacy is often recommended by fertility specialists when repeated IVF attempts fail despite using high-quality embryos, or when a previous pregnancy has made it physically unsafe or emotionally draining to try again.

Here are a few specific scenarios when doctors might recommend surrogacy:

• Multiple failed IVF cycles: If you’ve tried several IVF cycles with healthy embryos and still haven’t achieved a pregnancy, your doctor might suggest surrogacy. This could be due to issues like implantation failure, unexplained infertility or changes in the uterine environment that make pregnancy challenging.
• Complications from a previous pregnancy: If your first IVF pregnancy led to complications that would make carrying a second IVF pregnancy difficult, such as significant uterine scarring, placenta previa or preeclampsia, surrogacy could be a safer option.
• Age: In some cases, IVF fails due to age-related infertility. Surrogacy can help by using a healthy, younger surrogate to carry your embryo.

Why Surrogacy May Succeed After Failed IVF for Second Baby

A surrogate provides a healthy uterine environment, bypassing potential issues that may be preventing you from conceiving.

Surrogates undergo thorough screening to ensure they meet key health criteria. Factors like age, body mass index and previous pregnancy history are carefully evaluated to maximize the chances of a successful pregnancy.

Research supports this. One study shows that pregnancies carried by gestational surrogates have higher implantation, pregnancy and live birth rates than non-gestational carrier cycles (such as through IVF).

This makes surrogacy a promising option for parents who want to grow their family but aren’t getting pregnant again after IVF.

How Surrogacy Compares to IVF in Terms of Time

While IVF cycles can take several months, with limited success, surrogacy can provide a more predictable and quicker path, especially when multiple IVF attempts have failed.

Here’s a brief comparison of timelines:

IVF

Each round of IVF typically involves a few weeks of preparation, egg retrieval, embryo creation, and then a waiting period after the embryo transfer.

If IVF for a second baby fails, you’ll need to start the process over, which can lead to months or even years of frustration and uncertainty.

Surrogacy

Once a surrogate is selected and undergoes medical and psychological screening (which typically takes 1-2 months), the embryo transfer can be scheduled.

This means that even if your first IVF attempts have failed, surrogacy can often move you forward more quickly, bypassing certain hurdles that IVF might face.

After multiple failed second IVF pregnancy attempts, surrogacy offers a more direct and efficient path.

Learn more about the complete surrogacy timeline and surrogacy can fast track your path to parenthood.

How We Can Help You on Your Family-Building Journey

If a second IVF after the first success isn’t working, it doesn’t mean your family-building dreams have to end. In fact, exploring alternative options like surrogacy may be the key to growing your family when IVF alone isn’t enough.

At American Surrogacy, we understand how challenging and emotional the fertility process can be, and we’re here to offer you the guidance and support you need every step of the way.

From the moment you reach out, we’ll help you navigate the logistics of surrogacy with transparency and care.

Matching with the Right Surrogate – Fast

We understand that time is of the essence in your family-building journey, which is why we prioritize quick and efficient matching with a surrogate.

Thanks to our rigorous prescreening process and nationwide reach, we can connect you with qualified surrogates much faster than many other agencies.

This streamlined approach minimizes waiting times and helps get you one step closer to your dream of becoming parents.

Cost Transparency and Financial Protection

We understand that surrogacy can be a significant financial commitment, which is why we offer full cost transparency through every step of the process.

Our Limited Risk Program provides an added layer of financial protection, ensuring that your investment is safeguarded against unexpected costs.

You’ll have a clear understanding of what to expect, from surrogate compensation to medical and legal fees, and our program helps reduce the financial uncertainty that can sometimes accompany the surrogacy journey.

Emotional Support During Your Fertility Journey

Going through IVF, especially after a failed second IVF attempt, can take an emotional toll on you and your partner. It’s important to remember that it’s okay to feel frustrated, exhausted and overwhelmed.

Many people going through fertility struggles experience feelings of isolation or self-doubt. Here are some ways to take care of yourself:

• Take time for self-care: Practice mindfulness, meditation, or gentle exercise to reduce stress and improve your emotional well-being.
• Talk to a counselor or therapist: Seeking emotional support from a professional who specializes in fertility struggles can help you process the emotions involved and build coping strategies.
• Join a support group: Connecting with others who are going through similar experiences can offer you a sense of solidarity and understanding.
• Communicate with your partner: Fertility struggles affect both partners. Make sure to check in with each other regularly and offer emotional support throughout the journey.

Helpful Subreddits for Support

• r/IVFAfterSuccess: A supportive community for individuals who have previously achieved success with IVF and are now seeking to expand their families or are undergoing additional fertility treatments.
• r/InfertilitySucks: A supportive and open community for individuals dealing with infertility. It serves as a space for people to share their personal struggles, vent their frustrations and seek advice and encouragement.
• r/IVF: A community dedicated to individuals undergoing or considering in vitro fertilization (IVF) treatments. It serves as a place where people can discuss their IVF experiences, share information, offer support and ask for advice.

Taking the Next Step in Your Fertility Journey

If a second round of IVF after the first success isn’t working, it doesn’t mean your family-building dreams have to end. Surrogacy may be the right path forward, allowing you to have another child even when carrying a pregnancy yourself is no longer possible.

You don’t have to navigate this journey alone. Reach out to learn more about how surrogacy can help you achieve your dream of parenthood and take the next step toward building the family you’ve been hoping for.

Planning your family with IVF and surrogacy requires careful preparation, especially when using donor sperm.

One key decision is determining how many vials to purchase to increase your chances of success and plan for future children.

Below, we’ll break down the specifics of how many vials to purchase, what donor sperm costs and what to consider when selecting a donor.

Need help finding a fertility clinic? Fill out our contact form to get information about clinics and sperm banks who can help you complete your journey.

How Many Vials of Sperm Are Needed for IVF and Surrogacy?

Most individuals or couples using donor sperm for IVF will need about one to two vials per cycle.

A standard vial holds approximately 0.5 milliliters of sperm, with most donor sperm banks guaranteeing 10 to 20 million motile sperm per vial for IVF.

Purchasing multiple vials can be a smart strategy, especially if your embryos don’t make it to the blastocyst stage on the first attempt.

However, the exact number of vials you’ll need depends on several factors:

• Fertilization Method: If you’re using intracytoplasmic sperm injection (ICSI), where a single sperm is injected directly into an egg, one vial is often enough. However, for conventional IVF, where sperm and eggs are combined in a lab dish, higher sperm concentration is needed, which may require more than one vial.
• Sperm Quality: If sperm motility or count is lower than expected, your fertility specialist may recommend purchasing extra vials to improve fertilization chances.
• Embryo Freezing Plans: If you hope to create and freeze multiple embryos for future pregnancy attempts or sibling journeys, securing additional vials from the same donor can ensure consistency and avoid the risk of donor sperm selling out.

Consulting with your fertility clinic can help determine the right number based on your family-building goals.

Can You Use IUI Sperm for IVF?

Yes, you can use donor sperm from previous IUI attempts for IVF. IUI-prepped sperm is already washed and concentrated, making it suitable for IVF.

This can save you money since you won’t need to purchase additional sperm vials for IVF.

How Many Vials of Sperm Should I Freeze?

If you’re freezing your own sperm for future IVF treatments, the general guideline is the same as purchasing donor sperm: one to two vials per cycle.

However, many individuals choose to freeze multiple vials to prepare for additional cycles or to ensure they have enough for future children.

Freezing extra sperm vials for IVF ensures you have enough for multiple attempts. Your fertility clinic can help determine how many vials to store based on your reproductive goals and overall fertility plan.

How Long Can Sperm Be Stored?

Properly stored frozen sperm can be stored indefinitely without degrading. Sperm banks use liquid nitrogen tanks to maintain cryogenic temperatures, which preserves sperm quality for decades as long as storage conditions remain stable.

However, storage fees can add up over time, so it’s important to check with your sperm bank about long-term storage costs and policies. Some facilities offer pre-paid storage packages, while others charge annual fees.

How Much Does a Vial of Sperm Cost?

The cost of a vial of sperm can range from $400 to $2,000, depending on several factors. These include:

• Type of sperm: Sperm for home insemination may cost less than sperm prepared for a medical process like IVF.
• Sperm bank or agency: Prices vary depending on where you purchase the sperm.
• Donor status: Anonymous donor sperm may be more affordable than sperm from a known donor. For instance, Cryos charges more for vials with extended profiles, ID releases and adult photos.
• Sperm motility and quality: Higher motility sperm often comes at a higher price.
• Storage and shipping fees: Some facilities charge extra for long-term storage or expedited shipping.

If you’re planning for multiple cycles or future children, purchasing vials in bulk may offer discounts. Be sure to check with your donor sperm bank or agency about storage options and costs.

Need help budgeting for donor sperm in your surrogacy journey? Learn more about resources for affording surrogacy.

Does Insurance Cover Donor Sperm?

In most cases, insurance does not cover sperm vials for IVF. However, some plans may offer partial coverage if the sperm is needed due to moderate to severe male infertility.

It’s best to check with your insurance provider to understand your coverage and what out-of-pocket costs you may have.

How to Find a Sperm Donor

Choosing a sperm donor is an important decision. You’ll need to consider factors such as genetic history, physical traits and donor anonymity when making your selection.

Here’s how the process typically works:

• Step 1: Decide on donor anonymity. Choose between an anonymous donor, a known donor or an open-ID donor (who allows contact when the child reaches adulthood).
• Step 2: Browse sperm banks and agencies or find a personal donor.  Reputable sperm banks offer extensive donor profiles, including medical history and personal background. If you’re considering a personal donor, you’ll need to ensure they undergo thorough medical and genetic screening to meet fertility clinic requirements.
• Step 3: Review donor characteristics. Consider traits like ethnicity, education and personality to find the best match. There’s no guarantee that your child will have specific traits, but it may be important to you to share some characteristics.
• Step 4: Check medical screening results. Donors undergo genetic and infectious disease screening to ensure health and safety.
• Step 5: Purchase and store sperm. Once you select a donor, you will need to purchase and store the necessary sperm vials for IVF.

How Does Shipping Donor Sperm Work?

Once you’ve chosen a sperm donor, the sperm must be shipped to your fertility clinic. Sperm banks use cryogenic shipping containers, which keep the vials frozen at extremely low temperatures. These containers are designed to maintain sperm viability throughout transit.

You’ll need to coordinate with your clinic to ensure they receive the shipment on time.

You may want to look for a “sperm donor bank near me with expedited shipping,” otherwise you’ll need to provide advance notice and schedule a delivery.

Be sure to confirm shipping costs and timelines with your provider before placing an order.

Moving Forward With IVF and Surrogacy

Knowing how many sperm vials you’ll need for IVF and surrogacy can help you plan and make informed choices. Whether you’re purchasing donor sperm or freezing your own, having a clear strategy ensures a smoother fertility journey.

If you’re ready to move forward with your surrogacy journey, we can help you find a sperm bank and get started while you create your embryos. Contact us today.

While IVF has helped countless families, it’s not the right path for everyone.

By understanding key factors like maternal health, cost-effectiveness, emotional readiness and past IVF attempts, you can determine whether IVF or alternatives to IVF like surrogacy may be a better fit.

This guide will help you assess your options and take the next step with confidence.

If you’re having doubts about moving forward with IVF, we can discuss your options with you. Connect with a surrogacy specialist today to learn more about how surrogacy can help you become a parent.

Why Consider Surrogacy as an Alternative to IVF?

If you’re considering your options for starting a family, here’s why surrogacy may be a preferable alternative to IVF:

• Higher Success Rates: If you have medical conditions that could impact IVF success, surrogacy offers a more reliable path to parenthood.
• Avoid Physical Strain: IVF requires hormone injections, egg retrieval, and embryo transfer, which can be physically demanding. Surrogacy eliminates these challenges.
• Bypass Fertility Challenges: If you have uterine abnormalities, recurrent pregnancy loss, or other conditions that make carrying a pregnancy difficult, surrogacy may be a better option.
• More Cost-Effective: IVF can require multiple cycles, adding up financially. Surrogacy, while costly, is likely to be successful the first time, making it a more cost-effective alternative to IVF.
• Less Stressful: The ups and downs of IVF can be difficult. Surrogacy offers a more straightforward journey with professional support.
• Faster Path to Parenthood: If time is a concern, surrogacy may be a quicker alternative to IVF by helping you achieve your family-building goals sooner without undergoing multiple IVF cycles.

If you have embryos, you can begin the process of surrogacy and get matched with a surrogate quickly.

Is IVF Worth It?

Whether IVF is “worth it” depends on your situation and what you’re willing to invest in the process.

Here are key questions individuals or couples should ask themselves to determine if IVF is worth it for them:

• Do I have any underlying medical conditions that may impact IVF success?
• Can I afford multiple IVF cycles if the first attempt isn’t successful?
• Am I emotionally prepared for the potential ups and downs of the IVF process?
• Am I prepared for the physical demands of IVF, including hormone injections and frequent medical appointments?

If any of your answers to these questions indicate that IVF may not be worth it, you may want to consider surrogacy as an alternative to IVF.

How Many Times Should I Try IVF?

Many experts recommend reassessing your options after three failed cycles.
However, if IVF continues to fail, success rates tend to decline while emotional and financial stress increases.

 If IVF continues to be unsuccessful or your chances of pregnancy are unlikely, an alternative to IVF such as surrogacy may offer a higher chance of success.

If you’ve had multiple unsuccessful IVF attempts, speaking with your fertility doctor and a surrogacy specialist can help you determine if it’s time to explore a new path to parenthood.

Should I Do IVF Again?

Deciding whether to try again after a failed IVF cycle can be overwhelming. If these conditions apply to you, you may want to consider alternatives to IVF.

• You have one embryo left: If you only have one embryo left to transfer, there’s no guarantee that IVF will be successful. Options like surrogacy that use a thoroughly screened surrogate with a record of successful pregnancies may be a better option.
• You are not sure if you can afford another IVF cycle: If you’re not in a place where you can easily afford multiple IVF cycles, you may want to consider options that are more cost-effective. Surrogacy may cost more than IVF, but if multiple IVF cycles are needed, your total money spent could end up being more than the cost of surrogacy.
• You’re 40 or older: IVF success rates decline with age. Women under 35 have the highest success rates, while those over 40 see a significant drop. As ovarian reserve diminishes, using donor eggs or embryos may be necessary to improve chances.
• You have poor uterine health: Conditions like fibroids, endometriosis, or uterine abnormalities can make implantation difficult. If these issues persist despite treatment, surrogacy may be a viable alternative to IVF.
• You have underlying health conditions: Certain immune conditions, such as lupus or antiphospholipid syndrome, can make it challenging to achieve or maintain pregnancy. Conditions like diabetes, thyroid disorders, or clotting disorders can impact fertility and pregnancy outcomes.

If you’re down to your last embryo, surrogacy is an option for you. We’re one of the few surrogacy professionals that will work with single-embryo families because we believe you deserve the chance to experience parenthood, even if it requires more time and energy on our part.

Check out our surrogacy programs for one-embryo families.

2 Failed IVF Cycles: Should I Try Again?

If you’ve experienced two failed IVF cycles, it’s natural to question whether trying again is the right choice. Some families achieve success after multiple rounds, while others decide to pursue alternatives like surrogacy or adoption.

A consultation with your fertility specialist can provide clarity on your chances of success and whether another IVF cycle aligns with your family-building goals.

Is IVF Worth It at 40?

IVF success rates decline with age, but many families still achieve pregnancy in their late 30s and early 40s with the help of fertility treatments.

 If you’re 40 or older, your chances of success will depend on your egg quality, embryo health, and overall fertility. Options like egg freezing, donor eggs or surrogacy can improve success rates.

What Should I Do Now?

Whether IVF is worth it depends on various personal factors, including age, medical history, emotional readiness and financial capability.

If IVF success feels uncertain, surrogacy could be the right path for you. Contact a surrogacy specialist today to explore whether it could be the right alternative to IVF for you, especially if you’ve already experienced multiple IVF failures.

FAQs

What Are the Downsides of IVF?

While IVF can give many families a renewed hope in having the child they have been dreaming of, IVF comes with emotional, financial, and physical challenges, including stress, cost, and the uncertainty of success.

Should I Do IVF or Try Naturally?

The decision to pursue IVF or try to conceive on your own depends on factors such as age, fertility health, and previous conception history. Consult a fertility specialist to determine the best approach.

What Does No One Tell You About IVF?

Many people are unaware of the emotional highs and lows, potential setbacks, and the unpredictability of results. IVF can still be a great option, but it is important to be aware of  these challenges up front.

Is IVF Worth Doing?

IVF can be worth it for many families, but ultimately the decision to pursue IVF is highly personal. Consider your unique circumstances, financial situation, emotional resilience, and alternative options before making a choice.

If you’ve faced failed IVF cycles or don’t know what to do next, surrogacy offers a proven path to parenthood—with higher success rates and a predictable timeline.

In this guide, you’ll learn how surrogacy works for couples with unexplained infertility, why it might be the right choice for you, and what steps to take next.

Curious about surrogacy for couples with unexplained infertility? Fill out our form to speak with a surrogacy specialist about your unique situation.

Exploring Surrogacy for Couples with Unexplained Infertility

Surrogacy for couples with unexplained infertility bypasses many unknown barriers to conception.

If issues like implantation failure, uterine abnormalities, or endometrial receptivity are suspected but unconfirmed, surrogacy ensures an optimal environment for embryo development.

All of our surrogates are thoroughly prescreened before you have match with them. Their medical history is carefully reviewed, and they must have successfully carried at least one previous pregnancy to term to ensure they are fully prepared for the journey ahead.

When you have embryos, we can match you with a surrogate quickly. If you’re ready to move forward, it’s time to start your surrogacy process. Fill out this form to get matched with a surrogate.

Does IVF Work for Unexplained Infertility?

IVF can sometimes work for unexplained infertility, with roughly half of families achieving pregnancy, but for many couples diagnosed with unexplained infertility, IVF is unsuccessful.

Understanding Unexplained Infertility and Failed IVF

Even when the cause of infertility remains unexplained—understanding these potential challenges can help guide your next steps toward building your family.

Here’s a list of potential causes for failed IVF with unexplained infertility:

• Embryo implantation failure: The embryo may fail to implant in the uterus despite being healthy. This can be caused by issues related to the endometrial lining or immune system responses that interfere with implantation.
• Uterine or endometrial factors: In some cases, the uterus may not be receptive to an embryo, even if there’s no obvious medical condition. A thin or abnormal uterine lining, scarring, or fibroids could be undetected causes.
• Subtle hormonal imbalances: Small hormonal imbalances may not always show up in routine testing but can still affect embryo development, implantation, and pregnancy maintenance.
• Immunological factors: Some couples with unexplained infertility may have immune system disorders that impact embryo implantation, such as autoimmune diseases that attack the embryo.
• Genetic factors: Even without a known genetic disorder, minor genetic issues in either the egg or sperm can lead to poor embryo quality or failure to implant.

If you’ve experience multiple failed IVF cycles, surrogacy may provide a more reliable path to having a child.

If you don’t have viable embryos, you can still pursue surrogacy using donor embryos or donor eggs and sperm, giving you the chance to make your dreams of parenthood a reality.

Coping with Unexplained Infertility

Unexplained infertility can have life-changing effects on families, so it is normal to experience a wide variety of emotions including grief, sadness, confusion or frustration.

Here are some strategies to help you cope during this time:

• Allow yourself to grieve: It’s okay to feel upset about your situation. Give yourself permission to process these emotions.
• Seek professional support: Working with a counselor who specializes in infertility can provide you with tools to manage the emotional aspects of your journey.
• Lean on loved ones: Sharing your feelings with friends and family who understand can provide comfort and perspective.
• Join a support group: Connecting with others who are experiencing unexplained infertility through support groups like Hopeful Hearts Collective and Navigating Life and Loss With IVF, can offer solidarity and a sense of community.

While the emotional toll of unexplained infertility can be overwhelming, taking care of your mental health and finding support is key.

When you’re ready, exploring options like surrogacy can help you move forward with renewed hope and confidence.

Moving Forward After Unexplained Infertility: What Next?

If you’ve been diagnosed with unexplained infertility, surrogacy may be the key to creating the family you’ve dreamed of.

Take the first step by exploring how this process can work for you by filling out our quick form.

You can also keep up with infertility and surrogacy news when you follow us @american_surrogacy.

Frequently Asked Questions

Can you do surrogacy if you are infertile?

Surrogacy is still possible if you are infertile. Surrogacy can bypass uterine or implantation challenges, and you can use donor sperm and eggs or embryos if you do not have embryos with a high likelihood of success.

Is it possible to get pregnant with unexplained infertility?

In some cases couples spontaneously conceive after being diagnosed with unexplained infertility, but in other cases, unexplained fertility is a long-term problem that makes you unable to conceive without intervention.

What disqualifies you from surrogacy?

Individual surrogacy clinics and surrogacy agencies have their own criteria for what disqualifies you or qualifies you from completing surrogacy, and additionally, some states may have laws or regulations that restrict your ability to complete surrogacy.

One common requirement for surrogacy is medical need for surrogacy.

What is the most common reason that an infertile couple would choose surrogacy?

There are several reasons that infertile couples choose surrogacy including uterine issues, recurrent pregnancy loss, severe health risks, or failed fertility treatments.